Professor of Pediatrics, University Mich Medical School
Pediatric Hematology & Oncology
Dr. Valerie P. Castle, MD
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Doctor Valerie P. Castle, MD works in the field of Pediatric Hematology & Oncology. She researched medicine at McMaster University School of Medicine. She received 2 awards: "America's Top Doctors" and "America's Top Doctors for Cancer". Valerie Castle is also a published MD. She has 74 publication published. The most recent publication is: Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells.
Publications
- Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.
- Assessing the value of pediatric consultation services as bundled payments evolve: infectious Diseases as a model.
- Pediatric research impacts and benefits from all of biomedical science.
- United States Biomedical Research Impacting Child Health and the Growth of the National Institutes of Health Funding to Pediatric Departments and Children's Hospitals.
- Pediatric oncology in developing countries: challenges and solutions.
- CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.
- Thalidomide therapy for aggressive histiocytic lesions in the pediatric population.
- The role of pediatricians in the coordinated national effort to address childhood obesity.
- FDG PET imaging of childhood Sarcomas.
- Microscopic polyangiitis in an adolescent presenting as severe Anemia and syncope.
- Bcl6 is expressed in neuroblastoma: tumor Cell type-specific expression predicts outcome.
- The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD.
- Bortezomib as a therapeutic candidate for neuroblastoma.
- Tubedown expression correlates with the differentiation status and aggressiveness of neuroblastic tumors.
- Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic Cancer: synergistic action of estrogen metabolite and ligands of death receptor family.
- Histone deacetylase inhibition induces apoptosis in neuroblastoma.
- Delayed, recurrent opsoclonus-myoclonus syndrome responding to plasmapheresis.
- Ku70 acetylation mediates neuroblastoma Cell death induced by histone deacetylase inhibitors.
- Burkitt Lymphoma and Williams syndrome: a model for children with a multisystem disorder and malignancy.
- Chemotherapy-induced apoptosis of S-type neuroblastoma Cells requires caspase-9 and is augmented by CD95/Fas stimulation.
- Thoracic neural crest tumors in Beckwith-Wiedemann syndrome.
- Constitutively active NFkappa B is required for the survival of S-type neuroblastoma.
- N-myc modulates expression of p73 in neuroblastoma.
- Parotid carcinoma as a second malignancy after treatment of childhood Acute lymphoblastic leukemia.
- Clinical impact of neonatal thrombocytopenia.
- Frequency and mechanism of neonatal thrombocytopenia.
- The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbit.
- Development of the human coagulation system in the healthy premature infant.
- 111In-oxine platelet survivals in Thrombocytopenic infants.
- Modified bleeding time in the infant.
- NCCN pediatric neuroblastoma practice guidelines. The National Comprehensive Cancer Network.
- Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma.
- Virus-associated hemophagocytic syndrome following bone marrow transplantation.
- Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative Disease: a mimicker of sepsis in the pediatric intensive care unit.
- Isolated infraRenal caval disruption secondary to minimal blunt trauma.
- Ku70 acetylation in neuroblastoma pathogenesis and therapy.
- Making the National Children''s Study a real partnership with academic pediatrics.
- Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2.
- Bcl-xS enhances adenoviral vector-induced apoptosis in neuroblastoma Cells.
- Neuroblastoma: positron emission tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose compared with metaiodobenzylguanidine scintigraphy.
- Neonatal Purpura fulminans in association with factor V R506Q mutation.
- Congenital mesoblastic nephroma metastatic to the brain: a report of two cases.
- PET hydroxyephedrine imaging of neuroblastoma.
- High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth.
- Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.
- Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.
- Lineage switch in Philadelphia chromosome-positive Acute lymphoblastic leukemia.
- Neoplasms in a pediatric population: 2-[F-18]-fluoro-2-deoxy-D-glucose PET studies.
- Bcl-xL is expressed in neuroblastoma Cells and modulates chemotherapy-induced apoptosis.
- Insulin-like growth factor II in the pathogenesis of human neuroblastoma.
- The use of indium-111 oxine platelet scintigraphy and survival studies in pediatric patients with thrombocytopenia.
- Kasabach-Merritt syndrome: treatment with epsilon-aminocaproic acid and assessment by indium 111 platelet scintigraphy.
- NF-kappa B activation mediates doxorubicin-induced Cell death in N-type neuroblastoma Cells.
- Bcl-2 and M-Myc coexpression increases IGF-IR and features of malignant growth in neuroblastoma Cell lines.
- Successful bone marrow transplantation in a patient with Schimke immuno-osseous dysplasia.
- Fatal lymphoproliferative Disease as a complication of Evans syndrome.
- IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma.
- The response to splenectomy in pediatric patients with idiopathic thrombocytopenic purpura who fail high-dose intravenous Immune globulin.
- Thrombospondin-1 induces endothelial Cell apoptosis and inhibits angiogenesis by activating the caspase death pathway.
- Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.
- Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma Cells.
- Successful treatment of neonatal arterial thromboses with recombinant Tissue plasminogen activator.
- Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin.
- Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 Cells.
- Successful treatment of infantile hemangiomas with interferon-alpha-2b.
- Reversal of protein-losing enteropathy with heparin therapy in three patients with univentricular hearts and Fontan palliation.
- Induction of thrombospondin 1 by retinoic acid is important during differentiation of neuroblastoma Cells.
- Aggressive hepatic angiomyolipoma in a child.
- Signaling from p53 to NF-kappa B determines the chemotherapy responsiveness of neuroblastoma.
- Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma.
- CREB-binding protein is a mediator of neuroblastoma Cell death induced by the histone deacetylase inhibitor trichostatin A.
- HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma.
- CLU blocks HDACI-mediated killing of neuroblastoma.
Schools
McMaster University Faculty of Health Sciences
McMaster University Med Center
University Mich Hosps
Conditions Treated
- Acute Leukemia
- AdRenal Gland Cancer
- Anemia
- Immune Thrombocytopenic Purpura (ITP)
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
Education
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University of Michigan Hospitals and Health Centers -
McMaster University School of Medicine
Hospital
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University of Michigan Hospitals and Health Centers
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