Professor, Pathology (Basic Science), Case Western Reserve University School of Medicine

Pathology

Dr. Vincent M. Monnier, MD

Vincent Monnier practices Pathology. Vincent Monnier is also a published physician. He has 101 publication published. The most recent publication is: Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo.

Publications

Skin Advanced Glycation Endproducts (AGEs) Glucosepane and Methylglyoxal Hydroimidazolone are Independently Associated with Long-term Microvascular Complication Progre...
GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence.
An Advanced Glycation End Product (AGE)-Rich Diet Promotes NÃŽÂµ-Carboxymethyl-lysine Accumulation in the Cardiac Tissue and Tendons of Rats.
The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes.
Metabolic transit of N(?)-carboxymethyl-lysine after consumption of AGEs from bread crust.
The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis.
The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes.
Molecular Basis of Arterial Stiffening: Role of Glycation.
Advanced Glycation End-Products as Markers of Aging and Longevity in the Long-Lived Ansell's Mole-Rat (Fukomys anselli).
Oxygen Reactivity in Flavoenzymes: Context Matters.
Response to Comment on: Sun et al. Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration: The Joslin 50-Year Medalis...
Vitamin C degradation products and pathways in the human lens.
The Cation-?? Interaction Between Lys53 and the Flavin of Fructosamine Oxidase (FAOX-II) is Critical for Activity.
Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study.
Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.
Pudendal nerve injury reduces urethral outlet resistance in diabetic rats.
Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane.
Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis.
Partial characterization of the molecular nature of collagen-linked fluorescence: role of diabetes and end-stage renal disease.
Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.
Inhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging.
Crystal structure of the deglycating enzyme fructosamine oxidase (amadoriase II).
Identification of glucose-derived cross-linking sites in ribonuclease A.
RAGE and modulation of ischemic injury in the diabetic myocardium.
The role of the amadori product in the complications of diabetes.
Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediat...
Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model.
Isolation, purification and characterization of histidino-threosidine, a novel Maillard reaction protein crosslink from threose, lysine and histidine.
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.
Prevention and repair of protein damage by the Maillard reaction in vivo.
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
Ornithine is a novel amino acid and a marker of arginine damage by oxoaldehydes in senescent proteins.
Processing advanced glycation end product-modified albumin by the renal proximal tubule and the early pathogenesis of diabetic nephropathy.
Glycation products as markers and predictors of the progression of diabetic complications.
Cross-linking of the extracellular matrix by the maillard reaction in aging and diabetes: an update on "a puzzle nearing resolution".
Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes.
Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration ...
Apoptotic killing of fibroblasts by matrix-bound advanced glycation endproducts.
Conversion of arginine into ornithine by advanced glycation in senescent human collagen and lens crystallins.
Glycation stimulates amyloid formation.
Thioltranferase mediated ascorbate recycling in human lens epithelial cells.
Enzymatic deglycation of proteins.
Intervention against the Maillard reaction in vivo.
The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats.
The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates.
Vitamin C metabolomic mapping in experimental diabetes with 6-deoxy-6-fluoro-ascorbic acid and high resolution 19F-nuclear magnetic resonance spectroscopy.
Vitamin C metabolomic mapping in the lens with 6-deoxy-6-fluoro-ascorbic acid and high-resolution 19F-NMR spectroscopy.
Vitamin B1 blocks damage caused by hyperglycemia.
Wake up and smell the maillard reaction.
Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal.
Alteration of substrate selectivity through mutation of two arginine residues in the binding site of amadoriase II from Aspergillus sp.
Cellular oxidant stress and advanced glycation endproducts of albumin: caveats of the dichlorofluorescein assay.
2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis.
Collagen glycation triggers the formation of aged skin in vitro.
Favored and disfavored pathways of protein crosslinking by glucose: glucose lysine dimer (GLUCOLD) and crossline versus glucosepane.
Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes.
Dietary advanced lipoxidation products as risk factors for human health--a call for data.
Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin.
Plasma glucose and the action of calorie restriction on aging.
Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells.
The fructosamine 3-kinase knockout mouse: a tool for testing the glycation hypothesis of intracellular protein damage in diabetes and aging.
Green tea extract suppresses the age-related increase in collagen crosslinking and fluorescent products in C57BL/6 mice.
Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes contro...
Bacterial enzymes that can deglycate glucose- and fructose-modified lysine.
The veA gene is necessary for the inducible expression by fructosyl amines of the Aspergillus nidulans faoA gene encoding fructosyl amino acid oxidase (amadoriase, EC ...
Triosidines: novel Maillard reaction products and cross-links from the reaction of triose sugars with lysine and arginine residues.
Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264.7 cells through activation of mitogen-activating protein kinase, nuclear...
Kinetic studies, mechanism, and substrate specificity of amadoriase I from Aspergillus sp.
Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs C57BL/6 mice: the effect of dietary restriction.
Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of gl...
Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataract...
Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice.
Cloning of amadoriase I isoenzyme from Aspergillus sp.: evidence of FAD covalently linked to Cys342.
Transition metal-catalyzed oxidation of ascorbate in human cataract extracts: possible role of advanced glycation end products.
Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM.
Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia.
Tissue-specific effects of aldose reductase inhibition on fluorescence and cross-linking of extracellular matrix in chronic galactosemia. Relationship to pentosidine c...
High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.
Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.
Collagen browning and cross-linking are increased in chronic experimental hyperglycemia. Relevance to diabetes and aging.
Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease.
Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase.
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.
Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen.
The mechanism of collagen cross-linking in diabetes: a puzzle nearing resolution.
Purification and characterization of a membrane-bound deglycating enzyme (1-deoxyfructosyl alkyl amino acid oxidase, EC 1.5.3) from a Pseudomonas sp. soil strain.
Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes.
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress.
Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus sp.
Mechanisms for the formation of glycoxidation products in end-stage renal disease.
Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors.
End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen.
Differential effects of type 2 (non-insulin-dependent) diabetes mellitus on pentosidine formation in skin and glomerular basement membrane.
Enzymatic deglycation with amadoriase enzymes from Aspergillus sp. as a potential strategy against the complications of diabetes and aging.
Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat.
Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia.
Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo.
6-Deoxy-6-fluoro-L-ascorbic acid: crystal structure and oxidative degradation.
Chromatographic quantitation of plasma and erythrocyte pentosidine in diabetic and uremic subjects.

Doctors Specialties

Clinical Pathology
Pathology

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