Professor of Medicine, Beth Israel Deaconess Medical Center

Internal Medicine

William Aird is an expert in the field of Internal Medicine. Dr. William C. Aird is a published doctor. He has 102 publications published. The most current publication "Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus." William Aird is registered with Medicare.

Publications

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• Airway contractility in the precision-cut lung slice after cryopreservation.
• Plasmodium falciparum picks (on) EPCR.
• Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach.
• Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.
• Evolutionary origins of the blood vascular system and endothelium.
• Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium.
• Biomarkers of Endothelial Cell Activation in Early Sepsis.
• Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice.
• The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.
• Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis.
• ERG controls endothelial cell permeability via transcriptional regulation of claudin-5 (CLDN5).
• Genome-Wide Approaches Reveal Functional Interleukin-4-Inducible STAT6 Binding to the Vascular Cell Adhesion Molecule 1 Promoter.
• RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.
• Sepsis and the broken endothelium.
• Endothelial Cell Activation in Emergency Department Patients with Sepsis and Non-sepsis Related Hypotension.
• Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle.
• Multiple ETS Family Proteins Regulate PF4 Gene Expression by Binding to the Same ETS Binding Site.
• Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice.
• Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection.
• Proximate and evolutionary causation of endothelial heterogeneity.
• Under-recognized significance of endothelial heterogeneity: hemostasis, thrombosis, and beyond.
• Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood insti...
• Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3.
• Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.
• Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
• The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
• Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene.
• Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.
• Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells.
• Elevated levels of placental growth factor represent an adaptive host response in sepsis.
• A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.
• Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker.
• Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells.
• Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications ...
• A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis.
• NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.
• G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.
• The history of the capillary wall: doctors, discoveries, and debates.
• Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa.
• A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.
• Phenotypic heterogeneity of the endothelium: II. Representative vascular beds.
• Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.
• Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium.
• Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression.
• A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression.
• Vascular endocan is preferentially expressed in tumor endothelium.
• Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the...
• Endothelium and allotransplantation.
• Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.
• Mechanisms of endothelial cell heterogeneity in health and disease.
• Endothelial cell heterogeneity and atherosclerosis.
• Coagulation.
• Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell.
• Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia.
• Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells.
• Endothelial cell gene regulation.
• Sepsis and coagulation.
• Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap.
• CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17.
• Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis.
• Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB.
• Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.
• Endothelium as an organ system.
• Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells.
• The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP.
• Thrombin and phenotypic modulation of the endothelium.
• Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice.
• The hematologic system as a marker of organ dysfunction in sepsis.
• The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome.
• Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model.
• Endothelial cell heterogeneity.
• Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.
• Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome.
• The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells.
• Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice.
• Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set".
• Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-200. A 53-year-old man with a myocardial infarct and thromboses after...
• Endothelial cell dynamics and complexity theory.
• Functional vascular endothelium derived from human induced pluripotent stem cells.
• Influence of diabetes on endothelial cell response during sepsis.
• PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation.
• NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases.
• Long-term cryopreservation of human stem cells.
• Can oxygen consumption in blood in vitro be detected by a change in PCO2?
• Profound hypokalemia secondary to modest potassium depletion in a patient with coexisting hyponatremia: therapeutic implications.
• PR39, a peptide regulator of angiogenesis.
• Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based r...
• Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor.
• Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium.
• Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression.
• The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice.
• The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
• Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA site.
• NADPH oxidase activity is required for endothelial cell proliferation and migration.
• The endothelium and thrombosis.
• Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis.
• Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs.
• Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice.
• The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. A model of tissue-specific gene expression.
• Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus.
• VEGF-A/VEGFR Inhibition Restores Hematopoietic Homeostasis in the Bone Marrow and Attenuates Tumor Growth.

Doctors Specialties

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• Hematology
• Internal Medicine

Accepted Insurances

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Education

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• Brigham and Women's Hospital
• University of Western Ontario

Hospital

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• Beth Israel Deaconess Medical Center

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1881600229
Last Name Of The Provider	AIRD
First Name Of The Provider	WILLIAM
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