William E. Grizzle, M.D., Ph.D. Professor of Pathology University of Alabama at Birmingham
Pathology
Dr. William E. Grizzle, MD
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William Grizzle works in the field of Pathology. He attended Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical university. Johns Hopkins University School of Medicine has a rank of 3 in research and a 29 in primary care He has 37 awards "Member", "Consultant, Division of Cancer Biology and Diagnosis", "Reviewer (ad hoc) Study Sections", "Reviewer for the American Journal of Medicine", "Elected Member", "Biological Stain Commission Trustee", "Advisory Committee to the Director", "Ad Hoc Committee on Genetics and Medical Information Privacy", "Consultant", "Chair", "Pathology Reviewer (Breast)", "External Advisor", "Consultant in Tissue Resoruces for the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health", "Consultant in Tissue Resources for the Canadian Tumour Repository Network (CTRNet)", "Associate Editor for Cancer Biomarkers", "NCI Leadership Award", "Nominating Committee Chair", "Consultant, Cancer Therapy & Research Center (CTRC)", "President", "Executive Committee", "President Elect", "Biological Stain Commission President", "Co-Chair Minisymposium entitled Proteomics and Novel Technologies for diagnosis and Early Detection", "Chairman", "Associate Director", "Biological Stain Commission Vice President", "Board of Directors ISBER", "NROTC Full Scholarship", "Resident Teaching Award", "College of America Pathologists (CAP) House of Delegates, Alternate Delegate, Alabama", "House of Delegates", "CAP Faculty, Inspection Workshops", "Best Pathology Consultant", "CAP Commission on Laboratory Accreditation, Inspector", "Henry Strong Denison Scholarship for Excellence in Biomedical Researc", "Honors Degree" and "Consultant in Tissue Resources for the National Heart". Dr. William E. Grizzle is also published. He has 103 publications published. The lastest publication: "Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy.'
Publications
- Surveying the serologic proteome in a tissue specific kras(G12D) knockin mouse model of pancreatic cancer.
- Missed Opportunities and Lost Lives: Consequences of Some Proposed Changes to Regulations on Research with Human Tissues.
- The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampens tumor invasion-integrated analysis of expression and kinomics pathways.
- A Functional Anatomic Defect of the Cystic Fibrosis Airway.
- An Autoregulatory Mechanism Governing Mucociliary Transport is Sensitive to Mucus Load.
- Recurrent read-through fusion transcripts in breast cancer.
- Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling.
- Epithelial ovarian cancer: An overview.
- Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.
- NSAIDs inhibit tumorigenesis, but how?
- Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model.
- Effect of niclosamide on basal-like breast cancers.
- Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas.
- Retargeting of gene expression using endothelium specific hexon modified adenoviral vector.
- Exosomes: A Novel Pathway of Local and Distant Intercellular Communication that Facilitates the Growth and Metastasis of Neoplastic Lesions.
- L-Methionine inhibits growth of human pancreatic cancer cells.
- Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer.
- Significant variation of immunohistochemical marker expression in paired primary and metastatic clear cell renal cell carcinomas.
- Use of human specimens in research: the evolving United States regulatory, policy, and scientific landscape.
- MicroRNAs that affect prostate cancer: emphasis on prostate cancer in African Americans.
- It is primarily the control of transcription and post-transcriptional processing that are critical to the development and progression of sporadic neoplasias.
- An Undesired Effect of Chemotherapy: GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA...
- The Prognostic Value of MicroRNAs Varies with Patient Race/Ethnicity and Stage of Colorectal Cancer.
- Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
- Mouse model findings and the future of human tissue in disease research.
- Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells.
- Lung Resistance-Related Protein (LRP) Expression in Malignant Ascitic Cells as a Prognostic Marker for Advanced Ovarian Serous Carcinoma.
- Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography.
- A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.
- Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53.
- Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Varia...
- Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells.
- Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study.
- Validation of a robust proteomic analysis carried out on FFPE tissues of the pancreas obtained from mouse and human.
- CXCL12/CXCR4 signaling axis induces SHH expression in pancreatic cancer cells via ERK- and Akt- mediated activation of NF-κB: implications for bidirectional tumor-str...
- New NSAID targets and derivatives for colorectal cancer chemoprevention.
- A Critical Need for Increased Understanding of the Use of Human Tissues in Biomedical Research.
- A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease.
- Exosomes are endogenous nanoparticles that can deliver biological information between cells.
- A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
- Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential ro...
- Clinical and Biological Significance of KISS1 Expression in Prostate Cancer.
- miRNAs are stable in colorectal cancer archival tissue blocks.
- MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells.
- Extracelluar matrix metalloproteinase as a novel target for pancreatic cancer therapy.
- Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway.
- Early therapy evaluation of combined cetuximab and irinotecan in orthotopic pancreatic tumor xenografts by dynamic contrast-enhanced magnetic resonance imaging.
- Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer.
- LL-37 as a therapeutic target for late stage prostate cancer.
- (18)F-FDG PET/CT Imaging Detects Therapy Efficacy of Anti-EMMPRIN Antibody and Gemcitabine in Orthotopic Pancreatic Tumor Xenografts.
- Exosomes and cancer: a newly described pathway of immune suppression.
- Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.
- Serum biomarker panels for the detection of pancreatic cancer.
- DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapy.
- Inhibition of the catalytic function of activation-induced cytidine deaminase (AICDA) promotes apoptosis of germinal center B cells.
- A migration signature and plasma biomarker panel for pancreatic adenocarcinoma.
- Standards for immunohistochemical imaging: a protein reference device for biomarker quantitation.
- Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples.
- CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.
- A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseases.
- Prognostic value of mucin 4 expression in colorectal adenocarcinomas.
- Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation...
- Organizational issues in providing high-quality human tissues and clinical information for the support of biomedical research.
- Comparison of the predictive qualities of three prognostic models of colorectal cancer.
- Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines.
- Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance.
- Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression.
- Immature myeloid cells induced by a high-fat diet contribute to liver inflammation.
- Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model.
- Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1.
- Induction of myeloid-derived suppressor cells by tumor exosomes.
- How to efficiently obtain human tissues to support specific biomedical research projects.
- Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.
- Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma.
- Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
- Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working gr...
- Timing of consent for the research use of surgically removed tissue: is postoperative consenting acceptable?
- CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth.
- Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer.
- Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance ...
- Thymus exosomes-like particles induce regulatory T cells.
- Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer.
- Breast tumor xenografts: diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibody.
- Vascular endothelial growth factor reduces tamoxifen efficacy and promotes metastatic colonization and desmoplasia in breast tumors.
- Quality Assurance in Tissue Resources Supporting Biomedical Research.
- Effect of exercise and calorie restriction on biomarkers of aging in mice.
- Antibody responses of variable lymphocyte receptors in the lamprey.
- p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior.
- Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model.
- SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer.
- Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias.
- Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.
- Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix.
- Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis.
- TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth.
- Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: implications for the molecular analysis of clinically available biopsies.
- Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.
- Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer.
- Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.
- Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy.
- SPARC independent delivery of nab-paclitaxel without depleting tumor stroma in patient-derived pancreatic cancer xenografts.
- Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.
Schools
Johns Hopkins University School Of Medicine
Vanderbilt University Hospital
University Ala
Doctors Specialties
- Pathology
Accepted Insurances
Awards
- Member
- Consultant, Division of Cancer Biology and Diagnosis
- Reviewer (ad hoc) Study Sections
- Reviewer for the American Journal of Medicine
- Elected Member
- Biological Stain Commission – Trustee
- Advisory Committee to the Director
- Ad Hoc Committee on Genetics and Medical Information Privacy
- Consultant
- Chair
- Pathology Reviewer (Breast)
- External Advisor
- Consultant in Tissue Resoruces for the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health
- Consultant in Tissue Resources for the Canadian Tumour Repository Network (CTRNet)
- Associate Editor for Cancer Biomarkers
- NCI Leadership Award
- Nominating Committee Chair
- Consultant, Cancer Therapy & Research Center (CTRC)
- President
- Executive Committee
- President Elect
- Biological Stain Commission – President
- Co-Chair Minisymposium entitled “Proteomics and Novel Technologies for diagnosis and Early Detection
- Chairman
- Associate Director
- Biological Stain Commission – Vice President
- Board of Directors ISBER
- NROTC Full Scholarship
- Resident Teaching Award
- College of America Pathologists (CAP)– House of Delegates, Alternate Delegate, Alabama
- House of Delegates
- CAP – Faculty, Inspection Workshops
- Best Pathology Consultant
- CAP – Commission on Laboratory Accreditation, Inspector
- Henry Strong Denison Scholarship for Excellence in Biomedical Researc
- Honors Degree
- Consultant in Tissue Resources for the National Heart
Education
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Vanderbilt University -
Johns Hopkins University School of Medicine -
Johns Hopkins University -
Harvard University
Hospital
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University of Alabama Hospital
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