Professor of Medicine, George Washington University and the Veterans Administration Medical Center
Hematology
Dr. Charles S. Hesdorffer, MD
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Dr. Charles S. Hesdorffer works in the field of Hematology. He has 15 awards "Best Doctors (2004 to present)", "Best Doctor (2010 to present)", "Elected as a Fellow of the Royal Society of Medicine (FRSM)", "Dedication to Teaching and Patient Care Award", "Best Cancer Doctors in America", "Best Doctors in America", "Best Doctors in Baltimore", "Outstanding Teacher Award", "Best Doctors", "Best Doctors in New York", "National Leadership Award, Honorary Co-Chairman, Physicians Advisory Board - US Congressional Award", "Wild Awards", "Junior Faculty Teacher of the Year", "Gene Therapy Award" and "Jock Gear Memorial Prize". Dr. Charles S. Hesdorffer is a published MD. He published 27 publications, including: 'Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.'
Publications
- Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.
- Unexplained anaemia in the elderly is characterised by features of low grade inflammation.
- Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
- Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
- Association of the red cell distribution width with red Blood cell deformability.
- Distinctive immunoregulatory effects of adenosine on T cells of older humans.
- Epitope clustering in regions undergoing efficient proteasomal processing defines immunodominant CTL regions of a tumor antigen.
- Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma.
- Local deLivery of vaccinia virus expressing multiple costimulatory molecules for the treatment of established tumors.
- A phenotype based approach for the immune monitoring of NY-ESO-1-specific CD4+ T cell responses in Cancer patients.
- Quantitative and qualitative assessment of circulating NY-ESO-1 specific CD4+ T cells in Cancer-free individuals.
- Identification of B cell epitopes recognized by antibodies specific for the tumor antigen NY-ESO-1 in Cancer patients with spontaneous immune responses.
- A peripheral circulating compartment of natural naive CD4 Tregs.
- Initial clinical response predicts outcome and is associated with dose schedule in metastatic melanoma and renal cell carcinoma patients treated with high-dose interle...
- CD4+ T cell responses to SSX-4 in melanoma patients.
- Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2.
- Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic Breast cancer.
- The frequent expression of Cancer/testis antigens provides opportunities for immunotherapeutic targeting of sarcoma.
- Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells.
- An immunodominant SSX-2-derived epitope recognized by CD4+ T cells in association with HLA-DR.
- SSX antigens as tumor vaccine targets in human sarcoma.
- A monoclonal melanoma-specific T-cell population phenotypically indistinguishable from CD3+ LGL-Leukemia.
- Gene expression profiling and functional activity of human dendritic cells induced with IFN-alpha-2b: implications for Cancer immunotherapy.
- Decreased binding of peptides-MHC class I (pMHC) multimeric complexes to CD8 affects their binding avidity for the TCR but does not significantly impact on pMHC/TCR di...
- Shifting gene expression profiles during ex vivo culture of renal tumor cells: implications for Cancer immunotherapy.
- Multiepitope CD8(+) T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting.
Schools
University Of The Witwatersrand Faculty Of Health Sciences
Johannesburg Hospital
University Wittwatersrand Hospital
Presby Hospital Columbia PampS
Procedures Preformed
- Bone Marrow Transplant
- Lumbar Puncture
- Thoracentesis
Conditions Treated
- Anemia
- Autoimmune Disease in Pregnancy
- Blood Disorders
- Blood Disorders in Pregnancy
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Doctors Specialties
- Medical Oncology
- Oncology
- Hematology
Accepted Insurances
Awards
- Best Doctors (2004 to present)
- Best Doctor (2010 to present)
- Elected as a Fellow of the Royal Society of Medicine (FRSM)
- Dedication to Teaching and Patient Care Award
- Best Cancer Doctors in America
- Best Doctors in America
- Best Doctors in Baltimore
- Outstanding Teacher Award
- Best Doctors
- Best Doctors in New York
- National Leadership Award, Honorary Co-Chairman, Physicians Advisory Board - US Congressional Award
- Wild Awards
- Junior Faculty Teacher of the Year
- Gene Therapy Award
- Jock Gear Memorial Prize
Education
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University of the Witwatersrand
Hospital
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MedStar Harbor Hospital
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