Director, Clinical Development
Pediatric Gastroenterology
Dr. Joshua R. Friedman, MD
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Dr. Joshua R. Friedman works in the field of Pediatric Gastroenterology. He researched medicine at Perelman School of Medicine at the University of Pennsylvania. He has 13 awards "Best Doctor for Children (Pediatric Gastroenterology)", "Faculty Teaching Honor Roll, Division of Gastroenterology, CHOP", "Member, Society for Pediatric Research", "Researcher of the Year (American Liver Foundation, Delaware Valley Chapter)", "NASPGHAN Young Faculty Investigator Award", "Foerderer-Murray Award", "CHOP Fellow Research Day Prize", "The Children's Digestive Health and Nutrition Foundation Young Investigator Development Award", "First place in basic science research", "Rose Meadow Levinson Memorial Prize for research by a medical student", "Juan Grana Prize for research by a medical student", "Young Scientist Travel Grant" and "Harvard College Scholarship". Joshua Friedman is also a published doctor. He has 35 paper published. The most recent paper is: KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
Publications
- Pediatric eosinophilic esophagitis is associated with changes in Esophageal microRNAs.
- Rectal microRNAs are perturbed in pediatric inflammatory bowel Disease of the colon.
- Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets.
- Extra-Hepatic Cholangiocyte Cilia are Abnormal in Biliary Atresia.
- Dynamic recruitment of microRNAs to their MRNA targets in the regenerating liver.
- miR-122 regulates hepatic lipid metabolism and tumor suppression.
- Circulating MicroRNA is a Biomarker of Biliary Atresia.
- Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.
- MicroRNA Profiling Identifies miR-29 as a Regulator of Disease-Associated Pathways in Experimental Biliary Atresia.
- On the origin of the liver.
- MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS.
- Circulating microRNA is a biomarker of pediatric Crohn Disease.
- MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function.
- Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia.
- The microRNA-30 family is required for vertebrate hepatobiliary development.
- Hepatic function is preserved in the absence of mature microRNAs.
- Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
- A role for microRNA in cystic liver and kidney Diseases.
- Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.
- Foxl1-Cre BAC transgenic mice: a new tool for gene ablation in the gastrointestinal mesenchyme.
- Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2.
- Glucocorticoid receptor-dependent gene regulatory networks.
- The initiation of liver development is dependent on Foxa transcription factors.
- Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation.
- Foxa2 regulates multiple pathways of insulin secretion.
- Cases in pediatric gastroenterology from the Children's Hospital of Philadelphia: a 14-year-old boy with jaundice and pruritus.
- Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the M...
- An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene.
- Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain.
- Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interac...
- KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins...
- KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
- Kruppel-associated boxes are potent transcriptional repression domains.
- Novel targets of miR-30, a microRNA required for biliary development.
Schools
University Of Pennsylvania School Of Medicine
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Crohn's Disease (Regional Enteritis)
- Esophageal Achalasia and Cardiospasm
- Esophageal Varices
- View All
Doctors Specialties
- Pediatric Gastroenterology
Accepted Insurances
Awards
- Best Doctor for Children (Pediatric Gastroenterology)
- Faculty Teaching Honor Roll, Division of Gastroenterology, CHOP
- Member, Society for Pediatric Research
- Researcher of the Year (American Liver Foundation, Delaware Valley Chapter)
- NASPGHAN Young Faculty Investigator Award
- Foerderer-Murray Award
- CHOP Fellow Research Day Prize
- The Children's Digestive Health and Nutrition Foundation Young Investigator Development Award
- First place in basic science research
- Rose Meadow Levinson Memorial Prize for research by a medical student
- Juan Grana Prize for research by a medical student
- Young Scientist Travel Grant
- Harvard College Scholarship
Education
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Children's Hospital of Philadelphia -
Perelman School of Medicine at the University of Pennsylvania -
University of Pennsylvania School of Medicine -
Harvard University
Hospital
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Hospital of the University of Pennsylvania -
Pennsylvania Hospital
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