Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Pediatric Gastroenterology
Dr. Robert O. Heuckeroth, MD
Robert Heuckeroth works in the field of Pediatric Gastroenterology. He went to medical school at Washington University School of Medicine in St. Louis. He received awards:"Elected Member". Robert Heuckeroth is a published doctor. He published 54 publications, including: 'GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.'
Publications
- Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.
- Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.
- Enteric Nervous System Development: Migration, Differentiation, and Disease.
- In Reply To: Slow Growth: Do Not Forget Thyroid.
- Hypothyroidism is a rare cause of isolated constipation: 5-year review of all thyroid tests in a pediatric gastroenterology office.
- Differential Regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction.
- Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis.
- Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.
- The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.
- Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
- Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro.
- Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein liga...
- Tissue-type plasminogen activator deficiency exacerbates cholestatic liver injury in mice.
- Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung Disease-like...
- BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition.
- Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.
- Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice.
- Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival.
- A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the g...
- GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration.
- Finding your way to the end: a tale of GDNF and endothelin-3.
- Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca.
- Hypervariable region peptides variably induce specific anti-idiotypic antibodies: an approach to determining antigenic dominance.
- GDNF availability determines enteric neuron number by controlling precursor proliferation.
- Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons.
- RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.
- Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin.
- Anomalous development of the hepatobiliary system in the Inv mouse.
- Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons.
- GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.
- Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro.
- Persephin, a novel neurotrophic factor related to GDNF and neurturin.
- Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3.
- Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.
- TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.
- Neurturin, a relative of glial-cell-line-derived neurotrophic factor.
- The metabolic significance of mammalian fatty-acid-binding proteins: abundant proteins in search of a function.
- Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation.
- 11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransf...
- Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein.
- Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid.
- Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.
- Altered membrane association of p60v-src and a murine 63-kDa N-myristoyl protein after incorporation of an oxygen-substituted analog of myristic acid.
- Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.
- Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provid...
- Novel fatty acyl substrates for myristoyl-CoA:protein N-myristoyl-transferase.
- Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung Disease and delineate a direct role of Ret in spermatogenesis.
- Neurturin signalling via GFRalpha2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons.
- Getting to the guts of enteric nervous system development.
- Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
- PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA.
- Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
- Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor.
Schools
Washington Center School of Medicine
St Louis Chldrns Hospital
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Crohn's Disease (Regional Enteritis)
- Gastroesophageal Reflux Disease (GERD)
- Hepatitis B - Immune Response
- Intestinal Obstruction
- View All
Doctors Specialties
- Pediatric Gastroenterology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Local Value Network EPO
- Local Value Network HMO
- Local Value Network HMO+
- Local Value Network POS+
- Local Value Network PPO
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Great West Healthcare-Cigna PPO
- Commercial Insurance Company
- Coventry Health America PPO
- Coventry Health Care of Delaware PPO
- First Health (Coventry Health Care) PPO
- Geisinger Health Plan
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicaid
- Medicare MCR
- Molina
- MultiPlan PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- Elected Member
Education
-
Washington University School of Medicine in St. Louis
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