Professor, Pathology, Anatomy and Cell Biology, Jefferson Medical College-Thos Jefferson Univ

Pathology

Renato Iozzo works in the field of Pathology. He over the years received 1 awards: "CMS Meaningful Use Stage 1 Certification". Renato V. Iozzo has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Decorin as a multivalent therapeutic agent against cancer.'

Publications

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• Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases.
• Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers.
• Decorin as a multivalent therapeutic agent against cancer.
• Cosmetics for the matrix: An attractive new style for Matrix Biology.
• The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer.
• Instructive roles of extracellular matrix on autophagy.
• Endorepellin Evokes Autophagy in Endothelial Cells.
• Reprint of: Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.
• Decorin differentially modulates the activity of insulin receptor isoform A ligands.
• Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.
• Biglycan and decorin differentially regulate signaling in the fetal membranes.
• The injury response of aged tendons in the absence of biglycan and decorin.
• The Tendon Injury Response is Influenced by Decorin and Biglycan.
• The Location-Specific Role of Proteoglycans in the Flexor Carpi Ulnaris Tendon.
• Decorin has an appetite for endothelial cell autophagy.
• Decorin causes autophagy in endothelial cells via Peg3.
• Intracellularly-Retained Decorin Lacking the C-Terminal Ear Repeat Causes ER Stress: A Cell-Based Etiological Mechanism for Congenital Stromal Corneal Dystrophy.
• Endorepellin LG1/2 domains bind Ig3-5 of VEGFR2 and block proangiogenic signaling by VEGFA in endothelial cells.
• Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil cont...
• Dichotomy of decorin activity on the insulin-like growth factor-I system.
• Decorin Expression Is Important for Age-Related Changes in Tendon Structure and Mechanical Properties.
• Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model.
• Proline-Rich Tyrosine Kinase 2 (Pyk2) Regulates IGF-I-Induced Cell Motility and Invasion of Urothelial Carcinoma Cells.
• Decorin: A Guardian from the Matrix.
• Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon.
• Decorin-TGF B Axis in Hepatic Fibrosis and Cirrhosis.
• Uterine Dysfunction in Biglycan and Decorin Deficient Mice Leads to Dystocia during Parturition.
• Decorin antagonizes the angiogenic network: concurrent inhibition of Met, HIF-1? and VEGFA and induction of thrombospondin-1 and TIMP3.
• Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-Cadherin in vitro and in mice.
• The canonical Wnt pathway shapes niches supportive for hematopoietic stem/progenitor cells.
• The Role for Decorin in Delayed-Type Hypersensitivity.
• Autophagic tumor stroma: A biofuel for cancer growth.
• Pathophysiological Mechanisms of Autosomal Dominant Congenital Stromal Corneal Dystrophy C-Terminal-Truncated Decorin Results in Abnormal Matrix Assembly and Altered E...
• Decorin antagonizes IGF-IR function by interfering with IGF-IR activity and attenuating downstream signaling.
• Scleroderma-like properties of skin from caveolin-1 deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis.
• Endorepellin, perlecan angiostatic module, interacts with both the [alpha]2[beta]1 integrin and VEGFreceptor 2: A dual receptor antagonism.
• A Mouse Model of Spontaneous Preterm Birth Based on the Genetic Ablation of Biglycan and Decorin.
• A Role for Decorin in a Murine Model of Allergen-Induced Asthma.
• Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice.
• Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated ...
• Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells.
• Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21.
• Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
• Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans.
• Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.
• The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation...
• Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
• A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.
• Decorin is a novel antagonistic ligand of the Met receptor.
• A central role for decorin during vertebrate convergent extension.
• Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan.
• Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.
• Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
• Diverse cell signaling events modulated by perlecan.
• Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis.
• An antimetastatic role for decorin in breast cancer.
• Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway.
• Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.
• Novel interactions of perlecan: unraveling perlecan's role in angiogenesis.
• A central function for perlecan in skeletal muscle and cardiovascular development.
• Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity.
• Effect of PEEP on induced constriction is enhanced in decorin-deficient mice.
• Decorin deficiency enhances progressive nephropathy in diabetic mice.
• Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor.
• Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.
• Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.
• Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase act...
• Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activa...
• Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development.
• Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.
• A role for decorin in cutaneous wound healing and angiogenesis.
• Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation.
• Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
• Extracellular matrix proteoglycans control the fate of bone marrow stromal cells.
• A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival.
• Heparan sulfate: a complex polymer charged with biological activity.
• Decorin, a novel player in the insulin-like growth factor system.
• BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.
• Influence of decorin and biglycan on mechanical properties of multiple tendons in knockout mice.
• Alterations in lung mechanics in decorin-deficient mice.
• Protective niche for Borrelia burgdorferi to evade humoral immunity.
• Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury.
• Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.
• Investigating tendon fascicle structure-function relationships in a transgenic-age mouse model using multiple regression models.
• Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorin.
• Biologically active decorin is a monomer in solution.
• A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth.
• Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly.
• Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture.
• Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.
• Effect of altered matrix proteins on quasilinear viscoelastic properties in transgenic mouse tail tendons.
• In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer.
• Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan.
• Androgen receptor expression induces FGF2, FGF-binding protein production, and FGF2 release in prostate carcinoma cells: role of FGF2 in growth, survival, and androgen...
• Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope.
• Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol.
• The role of decorin in collagen fibrillogenesis and skin homeostasis.
• Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction.
• Isolation and purification of proteoglycans.
• Altered Proteoglycan Gene Expression in Human Biliary Cirrhosis.

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Awards

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• CMS Meaningful Use Stage 1 Certification

Education

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• University of Washington
• University of Florence Faculty of Medicine

Hospital

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• Thomas Jefferson University Hospital

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